ncRNA basic information
ncRNA ID:
MI0000443/MI0000444/MI0000445
ncRNA Database:
miRBase
ncRNA Name:
miR-124
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NR3C1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
NA
Drug Name:
Glucocorticoid
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
acute lymphocytic leukemia
Tissue/Cell:
cell line ( Human CCRF-CEM, Jurkat and CEM/C1)
Other information
Title:
MiR-124 contributes to glucocorticoid resistance in acute lymphoblastic leukemia by promoting proliferation, inhibiting apoptosis and targeting the glucocorticoid receptor.
Journal:
J Steroid Biochem Mol Biol
Published:
2017
PubMed ID:
28578002