ncRNA basic information
ncRNA ID:
MI0003653
ncRNA Database:
miRBase
ncRNA Name:
miR-638
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
STARD10
ncRNA Pathway:
STARD10 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01248 (APRD00932)
Drug Name:
Docetaxel
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Apoptosis measurement was used to test the drug-resistant phenotype changes in cancer cells
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (T47D, MCF-7, MDA-MB-231 and MDA-MB-468)
Other information
Title:
Potentiation of docetaxel sensitivity by miR-638 via regulation of STARD10 pathway in human breast cancer cells.
Journal:
Biochem Biophys Res Commun
Published:
2017
PubMed ID:
28412359