ncRNA basic information
ncRNA ID:
MIMAT0000232
ncRNA Database:
miRBase
ncRNA Name:
miR-199a-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-time reverse transcription-PCR,Semiquantitative reverse transcription-PCR
ncRNA Target Gene:
mTOR
ncRNA Pathway:
mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Real-time reverse transcription-PCR . Luciferase activity assay was used to verify the target genes of miRNAs.Cell migration was detected by invasion assay, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocarcinoma
Tissue/Cell:
cell line ( HepG2,Huh-7,SNU475)
Other information
Title:
MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells.
Journal:
Cancer Res
Published:
2010
PubMed ID:
20501828