ncRNA basic information
ncRNA ID:
MI0000469
ncRNA Database:
miRBase
ncRNA Name:
miR-125a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
GRK2 and Puma
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00694 (APRD00521)
Drug Name:
Daunorubicin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs .
Drug Response:
resistant
Cancer basic information
Cancer:
leukemia
Tissue/Cell:
cell line ( HL-60, K562, THP-1, and HEK293T)
Other information
Title:
Involvement of miR-125a in resistance to daunorubicin by inhibiting apoptosis in leukemia cell lines.
Journal:
Tumour Biol
Published:
2017
PubMed ID:
28381182