ncRNA basic information
ncRNA ID:
MIMAT0004748
ncRNA Database:
miRBase
ncRNA Name:
miR-423-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
the mitochondrial pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB07352
Drug Name:
Apigenin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioma
Tissue/Cell:
tissue and cell line
Other information
Title:
miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway.
Journal:
Tumour Biol
Published:
2017
PubMed ID:
28381178