ncRNA basic information
ncRNA ID:
MI0000066
ncRNA Database:
miRBase
ncRNA Name:
Let-7e
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
epithelial ovarian cancer
Tissue/Cell:
tissue and cell line ( A2780, HO8910, ES2, CAOV3 and SKOV3 )
Other information
Title:
Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair.
Journal:
J Ovarian Res
Published:
2017
PubMed ID:
28376831