ncRNA basic information
ncRNA ID:
MI0000300
ncRNA Database:
miRBase
ncRNA Name:
miR-223
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PAX6
ncRNA Pathway:
PI3K/Akt Pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
tissue and cell line
Other information
Title:
MiR-223/PAX6 Axis Regulates Glioblastoma Stem Cell Proliferation and the Chemo Resistance to TMZ via Regulating PI3K/Akt Pathway.
Journal:
J Cell Biochem
Published:
2017
PubMed ID:
28332226