ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
Bcl-2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In the present study, miR-125b expression in cisplatin (DDP) -resistant CNE2 cells (CNE2/DDP) was compared with parental counterparts, using reverse transcription-quantitative polymerase chain reaction. A >3-fold reduction in miR-125b expression levels was observed in CNE2/DDP cells compared with parental CNE2 cells. Ectopic expression of miR-125b by transfecting CNE2/DDP cells with miR-125b mimics, increased DDP-induced cytotoxicity, apoptosis and chemosensitivity. By contrast, suppression of miR-125b by transfecting CNE2 cells with miR-125b inhibitors, reduced DDP-induced cytotoxicity and apoptosis, and facilitated cisplatin resistance. The results suggest that miR-125b may regulate the sensitivity of NPC cells to DDP by modulating the expression levels of antiapoptotic factor B-cell CLL/lymphoma 2.
Drug Response:
sensitive
Cancer basic information
Cancer:
nasopharyngeal carcinoma
Tissue/Cell:
cell line ( CNE2, CNE2/DDP)
Other information
Title:
microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2.
Journal:
Mol Med Rep
Published:
2017
PubMed ID:
28260044