ncRNA basic information
ncRNA ID:
MIMAT0000423
ncRNA Database:
miRBase
ncRNA Name:
miR-125b-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
BCL2
ncRNA Pathway:
miR-125b-5p-Bcl2 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined byReal-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
gallbladder cancer
Tissue/Cell:
tissue and cell line ( HEK293FT, NOZ, GBC-SD,SGC-996 )
Other information
Title:
miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer.
Journal:
Sci Rep
Published:
2017
PubMed ID:
28256505