ncRNA basic information
ncRNA ID:
MI0000289/MI0000269
ncRNA Database:
miRBase
ncRNA Name:
miR-181a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
p53 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01073 (APRD00594)
Drug Name:
Fludarabine
Drug Method:
In the study, we performed an analysis of genomic aberrations, gene expression profiles, and microRNAs expression in CLL blood B lymphocytes isolated during the course of patients treatment with fludarabine.The expression levels of miRNA were determined by Quantitative RT-PCR The CCK-8 assay was used to monitor the growth of the cells,etc.
Drug Response:
resistant
Cancer basic information
Cancer:
chronic lymphocytic leukemia
Tissue/Cell:
tissue and cell line
Other information
Title:
Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.
Journal:
Mol Cancer
Published:
2010
PubMed ID:
20487546