ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00619 (APRD01028, EXPT02967, DB03261)
Drug Name:
Imatinib
Drug Method:
The expression levels of miRNA were determined by real-time quantitative PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.The CCK-8 assay was used to monitor the growth of the cells .
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myeloid leukemia
Tissue/Cell:
cell line ( K562 )
Other information
Title:
LncRNA MEG3 Regulates Imatinib Resistance in Chronic Myeloid Leukemia via Suppressing MicroRNA-21.
Journal:
Biomol Ther (Seoul)
Published:
2017
PubMed ID:
28190319