ncRNA basic information
ncRNA ID:
MI0000748
ncRNA Database:
miRBase
ncRNA Name:
miR-130b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
PI3K/AKT signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Adriamycin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.he CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MCF-7 and the MCF-7/ADR)
Other information
Title:
MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway.
Journal:
Sci Rep
Published:
2017
PubMed ID:
28165066