ncRNA basic information
ncRNA ID:
MI0003123
ncRNA Database:
miRBase
ncRNA Name:
miRNA-488
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
eIF3a
ncRNA Pathway:
NER pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis. Using bioinformatics analysis prediction and confirmation with dual-luciferase reporter assays, we found the target genes of miRNAs
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line ( A549 and H1299)
Other information
Title:
MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway.
Journal:
Sci Rep
Published:
2017
PubMed ID:
28074905