ncRNA basic information
ncRNA ID:
MI0003138
ncRNA Database:
miRBase
ncRNA Name:
miR-497
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
mTOR/Bcl-2
ncRNA Pathway:
IGF1R/IRS1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
glioma
Tissue/Cell:
cell line (SF295, SHG-44, U138, LN382, U87, U251, HEK-293)
Other information
Title:
Up-regulation of miR-497 confers resistance to temozolomide in human glioma cells by targeting mTOR/Bcl-2.
Journal:
Cancer Med
Published:
2017
PubMed ID:
28064447