ncRNA basic information
ncRNA ID:
MI0000294/MI0000295
ncRNA Database:
miRBase
ncRNA Name:
miR-218
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
PCR
ncRNA Target Gene:
BCAT1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, we explored miR-218 increased the chemosensitivity to cis-diaminedichloroplatinum treatment of prostate cancer. We found that the expression level of miR-218 was down-regulated in the human prostate cancer specimens. Moreover, overexpression of miR-218 inhibited cell viability, migration and invasion in PC3 and DU145 cells. Furthermore, we demonstrated that the tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression. Importantly, overexpression of BCAT1 decreased the chemosensitivity to CDDP treatment of PC3 and DU145 cells.
Drug Response:
resistant
Cancer basic information
Cancer:
prostate cancer
Tissue/Cell:
cell line (PC3, DU145 )
Other information
Title:
MicroRNA-218 inhibits tumor growth and increases chemosensitivity to CDDP treatment by targeting BCAT1 in prostate cancer.
Journal:
Mol Carcinog
Published:
2017
PubMed ID:
28052414