ncRNA basic information
ncRNA ID:
MIMAT0000765
ncRNA Database:
miRBase
ncRNA Name:
miR-335-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
ERalpha signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Quantitative information of cell relative density was obtained by crystal violet assay
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( MCF-7,MCF-7-TR and MCF-7-FR )
Other information
Title:
MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance.
Journal:
FEBS Lett
Published:
2017
PubMed ID:
28008602