ncRNA basic information
ncRNA ID:
MIMAT0004784
ncRNA Database:
miRBase
ncRNA Name:
miR-455-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
LHX2,ALS2CR8,DIP2A,DYNLL2,C6orf145,FBXL15,LTBR,ASB1,PNPLA6,RTN4,RUSC1,EI24,HSF1,SMAD2,GNL1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
In the study, we first established a resistant variant, U251R cells from TMZ-sensitive GBM cell line, U251MG. We then performed a comprehensive analysis of miRNA expressions in U251R and parental cells using miRNA microarrays. miR-195, miR-455-3p and miR-10a( *) were the three most up-regulated miRNAs in the resistant cells. To investigate the functional role of these miRNAs in TMZ resistance, U251R cells were transfected with miRNA inhibitors consisting of DNA/LNA hybrid oligonucleotides. In addition, using in silico analysis combined with cDNA microarray experiment, we present possible mRNA targets of these miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (U251MG,U87MG, M059K and M059J)
Other information
Title:
miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells.
Journal:
Cancer Lett
Published:
2010
PubMed ID:
20444541