ncRNA basic information
ncRNA ID:
MI0000681
ncRNA Database:
miRBase
ncRNA Name:
miR-155
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Northern blot,qRT-PCR
ncRNA Target Gene:
FOXO3a
ncRNA Pathway:
factor-Beta/Smad pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by Northern Blot,and qRT-PCR . Those of protein were by Western blot analysis.Luciferase activity assay was used to verify the target genes of miRNAs. Cell Viability and Apoptosis Assays used to identify the relationship between miR-155 and chemosensitivity by targeting FOXO3a in breast cancer.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (BT-474,MDA-MB-157, MDA-MB-435, HS578T)
Other information
Title:
MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer.
Journal:
J Biol Chem
Published:
2010
PubMed ID:
20371610