ncRNA basic information
ncRNA ID:
MI0000745
ncRNA Database:
miRBase
ncRNA Name:
miR-301a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
Akt and FAK signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Quantitative real-time PCR (qRT-PCR) assay was performed to detect the expression of miR-301a in MM tissues, and analyze its correlation with metastasis and prognosis of MM patients. In vitro, miR-301a was ectopically expressed using overexpression and knock-down strategies, and the effects of miR-301a expression on growth, apoptosis, migration, invasion and chemosensitivity of MM cells were further investigated. Furthermore, the potential and functional target gene was identified by luciferase reporter, qRT-PCR, Western blot assays.
Drug Response:
resistant
Cancer basic information
Cancer:
melanoma
Tissue/Cell:
cell line (SK-MEL-1, A-375)
Other information
Title:
Expression of MicroRNA-301a and its Functional Roles in Malignant Melanoma.
Journal:
Cell Physiol Biochem
Published:
2016
PubMed ID:
27855389