ncRNA basic information
ncRNA ID:
MI0000089
ncRNA Database:
miRBase
ncRNA Name:
miR-31
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Src
ncRNA Pathway:
miR-31/Src/Akt/Bax/Bcl-2 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The microarray was used to select the candidate miRNA in two DDP-resistant GBC cell lines. The effect of regulated expression of the miRNA on cell migration, invasion, proliferation and apoptosis was examined by wound healing, transwell assays, CCK-8 assays, colony formation and flow cytometry assays, respectively. Xenograft tumor models were used to validate the function of the downstream target.
Drug Response:
sensitive
Cancer basic information
Cancer:
gallbladder cancer
Tissue/Cell:
cell line (NOZ, GBC-SD,NOZ/DDP,GBC-SD/DDP)
Other information
Title:
MiR-31 regulates the cisplatin resistance by targeting Src in gallbladder cancer.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27825112