ncRNA basic information
ncRNA ID:
MIMAT0004602
ncRNA Database:
miRBase
ncRNA Name:
miR-125a-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
BRCA1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01248 (APRD00932)
Drug Name:
Docetaxel
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MCF-7, MCF-7/LCC2, MDA-MB-468, MDA-MB-231, MDA-MB-468/R, MCF-7/R,MDA-MB-468/S, MCF-7/S)
Other information
Title:
Enforced expression of hsa-miR-125a-3p in breast cancer cells potentiates docetaxel sensitivity via modulation of BRCA1 signaling.
Journal:
Biochem Biophys Res Commun
Published:
2016
PubMed ID:
27693788