ncRNA basic information
ncRNA ID:
MI0001729
ncRNA Database:
miRBase
ncRNA Name:
miR-451
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
Mcl-1
ncRNA Pathway:
miR-451/Mcl-1/DPP
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549, A549/DPP)
Other information
Title:
MicroRNA-451 sensitizes lung cancer cells to cisplatin through regulation of Mcl-1.
Journal:
Mol Cell Biochem
Published:
2016
PubMed ID:
27686452