ncRNA basic information
ncRNA ID:
MI0000471
ncRNA Database:
miRBase
ncRNA Name:
miR-126
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
EZH2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Caspase-3 and -7 activation status was measured using the Caspase-Glo 3/7 Assay .The CCK-8 assay was used to monitor the growth of the cells .
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC7901/VCR,SGC7901/ADR,SGC7901)
Other information
Title:
MicroRNA-126 increases chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2.
Journal:
Biochem Biophys Res Commun
Published:
2016
PubMed ID:
27622325