ncRNA basic information
ncRNA ID:
MI0000789
ncRNA Database:
miRBase
ncRNA Name:
miR-381
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
LRRC4
ncRNA Pathway:
mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time PCR (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
tissue and cell line ( MG-63 )
Other information
Title:
Low expression of miR-381 is a favorite prognosis factor and enhances the chemosensitivity of osteosarcoma.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27612424