ncRNA basic information
ncRNA ID:
MI0000271
ncRNA Database:
miRBase
ncRNA Name:
miR-181c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ST8SIA4
ncRNA Pathway:
PI3K/AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Adriamycin
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.The CCK-8 assay was used to monitor the growth of the cells,
Drug Response:
sensitive
Cancer basic information
Cancer:
chronic myelocytic leukemia
Tissue/Cell:
cell line (K562, KCL22, KU812,K562/ADR, KCL22/ADR, and KU812/ADR)
Other information
Title:
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27527856