ncRNA basic information
ncRNA ID:
MIMAT0003948
ncRNA Database:
miRBase
ncRNA Name:
miR-770-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR,RT-PCR
ncRNA Target Gene:
ERCC2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative Real-Time PCR (qRT-PCR) and Reverse transcription PCR .Those of protein were by Western blot analysis. A comet assay confirmed that this restoration of cisplatin chemosensitivity was due to the inhibition of DNA repair.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line ( A2780S, OV2008, A2780CP, C13)
Other information
Title:
MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27449101