ncRNA basic information
ncRNA ID:
MI0000072
ncRNA Database:
miRBase
ncRNA Name:
miR-18
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
20 TNBC patients who received neoadjuvant chemotherapy before surgery were recruited. MiR-18a expression was quantified using QRT-PCR. The effects of miR-18a overexpression or knockdown on cell viability and apoptosis of PTX sensitive MDA-MB-231 cells and PTX resistant MDA-MB-231 cells after PTX treatment were studied. The influence of miR-18a overexpression on Dicer expression was measured by qRT-PCR and Western blot analysis.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MB-231,MDA-MB-468,MCF-10A,)
Other information
Title:
MiR-18a upregulation decreases Dicer expression and confers paclitaxel resistance in triple negative breast cancer.
Journal:
Eur Rev Med Pharmacol Sci
Published:
2016
PubMed ID:
27338043