ncRNA basic information
ncRNA ID:
MI0000301
ncRNA Database:
miRBase
ncRNA Name:
miR-224
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Rac1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells
Drug Response:
sensitive
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
tissue and cell line (MG-63, U2OS, SOSP-9607 and SAOS-2)
Other information
Title:
MicroRNA-224 promotes the sensitivity of osteosarcoma cells to cisplatin by targeting Rac1.
Journal:
J Cell Mol Med
Published:
2016
PubMed ID:
27222381