ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
CADM1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNAs and mRNAs were determined by Real-time PCR. Those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
tongue cancer
Tissue/Cell:
tissue and cell line ( SCC-25, CAL-27)
Other information
Title:
MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer.
Journal:
J Mol Med (Berl)
Published:
2016
PubMed ID:
27055844