ncRNA basic information
ncRNA ID:
MI0000476/MI0000455
ncRNA Database:
miRBase
ncRNA Name:
miR-138
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
EZH2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.Cell migration was detected by invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
tissue and cell line (NHOst, hFOB1.19,HOS, Saos-2, MG-63, U2OS)
Other information
Title:
MiR-138 Acts as a Tumor Suppressor by Targeting EZH2 and Enhances Cisplatin-Induced Apoptosis in Osteosarcoma Cells.
Journal:
PLoS One
Published:
2016
PubMed ID:
27019355