ncRNA basic information
ncRNA ID:
MI0000490
ncRNA Database:
miRBase
ncRNA Name:
miR-206
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MET
ncRNA Pathway:
PI3K/AKT /mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The aims of this study were to explore the potential role of miR-206 in governing cisplatin resistance and EMT in lung cancer cells.The expression levels of miRNA were determined by Quantitative real-time PCR analysis and those of protein were by Western blot analysis. luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
cell line (A549, H1299 and A549/DDP)
Other information
Title:
miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27014910