ncRNA basic information
ncRNA ID:
MI0000085
ncRNA Database:
miRBase
ncRNA Name:
miR-27a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PLAG1
ncRNA Pathway:
apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
NA
Drug Name:
TRAIL therapy
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line (HL-60, HL-60/ADM, K562, K562/A02, NB4 )
Other information
Title:
MiR-424 and miR-27a increase TRAIL sensitivity of acute myeloid leukemia by targeting PLAG1.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27013583