ncRNA basic information
ncRNA ID:
MI0000070/MI0000115
ncRNA Database:
miRBase
ncRNA Name:
miR-16
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
IKBKB
ncRNA Pathway:
NF-kappaB pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by quantitative RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MDA-MB-231, MCF-7 )
Other information
Title:
MicroRNA-16 sensitizes breast cancer cells to paclitaxel through suppression of IKBKB expression.
Journal:
Oncotarget
Published:
2016
PubMed ID:
26993770