ncRNA basic information
ncRNA ID:
MI0000454
ncRNA Database:
miRBase
ncRNA Name:
miR-137
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR,qRT-PCR
ncRNA Target Gene:
NUCKS1
ncRNA Pathway:
PI3K/AKT pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by reverse transcription PCR and quantitative real time-PCR . Those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line (A549, A549/PTX, A549/CDDP )
Other information
Title:
MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancer.
Journal:
Oncotarget
Published:
2016
PubMed ID:
26989074