ncRNA basic information
ncRNA ID:
MI0000290
ncRNA Database:
miRBase
ncRNA Name:
miR-214
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, miRNA microarray was firstly used to compare the differential miRNAs levels between the cisplatin-sensitive tongue squamous cell carcinoma line (Tca8113) and its cisplatin-resistant subline (Tca/cisplatin). Three miRNAs of miR-21, -214, and -23a were validated by miRNAs real-time PCR, and intervened by anti-miRNA oligonucleotides (miR-214 and -23a) and pre-miRNA plasmid transfection (miR-21). Further relationship between miR-23a and DNA topoisomerase II Beta (TOP2B) on the chemoresistance against cisplatin was studied.
Drug Response:
resistant
Cancer basic information
Cancer:
tongue squamous cell carcinoma
Tissue/Cell:
cell line (Tca8113,Tca/cisplatin)
Other information
Title:
MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines.
Journal:
Oral Oncol
Published:
2010
PubMed ID:
20219416