ncRNA basic information
ncRNA ID:
ENSG00000249859
ncRNA Database:
Ensembl
ncRNA Name:
PVT1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We used small interfering RNA (siRNA)-mediated knockdown in MPM cell lines to determine the effect of C-MYC and PVT1 abrogation on MPM cells undergoing apoptosis, proliferation, and cisplatin sensitivity. We also characterized the expression of microRNAs spanning the PVT1 region in MPM cell lines. Copy number analysis was measured by quantitative polymerase chain reaction and fluorescence in situ hybridization.
Drug Response:
sensitive
Cancer basic information
Cancer:
malignant pleural mesothelioma
Tissue/Cell:
cell line (H2452, MET-5A, H2052, H28,MSTO-211H,HCT-4012, Meso, HP3, HP5, HP7, HP9 and HP10)
Other information
Title:
Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma.
Journal:
J Thorac Oncol
Published:
2014
PubMed ID:
24926545