ncRNA basic information
ncRNA ID:
MI0005564
ncRNA Database:
miRBase
ncRNA Name:
miR-873
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ABCB1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. Experiments in a mouse xenograft model confirmed that the relationship between miR-873 and cisplatin in ovarian cancer in vivo
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line ( OVCAR3, A2780)
Other information
Title:
MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1
Journal:
Tumour Biol
Published:
2016
PubMed ID:
26850595