ncRNA basic information
ncRNA ID:
MI0003132
ncRNA Database:
miRBase
ncRNA Name:
miR-493
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
real-time RT-PCR
ncRNA Target Gene:
DKK1
ncRNA Pathway:
miR-493/DKK1 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by real-time RT-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTS assay was used to test cell proliferation.Cell migration was detected by transwell migration .
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (SGC-7901, MKN28, AGS, MGC-803)
Other information
Title:
miR-493 mediated DKK1 down-regulation confers proliferation, invasion and chemo-resistance in gastric cancer cells.
Journal:
Oncotarget
Published:
2016
PubMed ID:
26799283