ncRNA basic information
ncRNA ID:
MIMAT0002881
ncRNA Database:
miRBase
ncRNA Name:
miR-509-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
XIAP
ncRNA Pathway:
the apoptotic pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The regulation of XIAP by miR-509-3p was investigated by luciferase reporter assay, real-time PCR and immunobloting, and the roles of miR-509-3p in cellular proliferation and apoptosis were accessed through MTT and DAPI assays.
Drug Response:
sensitive
Cancer basic information
Cancer:
epithelial ovarian cancer
Tissue/Cell:
cell line (HEK-293T, A2780 and,
Other information
Title:
MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis.
Journal:
Pharmacogenomics
Published:
2016
PubMed ID:
26786897