ncRNA basic information
ncRNA ID:
MI0000102
ncRNA Database:
miRBase
ncRNA Name:
miR-100
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
mTOR
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The expression levels of miRNA were determined by RT-PCR and real-time PCR and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells.Tumor development in nude mice demonstrated the relationship between miR-100 expression and paclitaxel treatment in endoluminal breast cancer.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (T-47D, MCF-7, ZR-75-1, BT-549, MDA-MB-231 and Hs578T)
Other information
Title:
MicroRNA 100 sensitizes luminal A breast cancer cells to paclitaxel treatment in part by targeting mTOR.
Journal:
Oncotarget
Published:
2016
PubMed ID:
26744318