ncRNA basic information
ncRNA ID:
MIMAT0004748
ncRNA Database:
miRBase
ncRNA Name:
miR-423-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Expression levels of known miRNAs in SCLC cell line H446 and its multidrug-resistant cell line H446/CDDP were analyzed using the next generation high through-put Illumina Solexa sequencing technology, and expression of a group of specific miRNAs was validated by quantitative polymerase chain reaction (qPCR). Furthermore, novel miRNAs and their putative target genes in the two SCLC cell lines were predicted with the help of software developed by Beijing Genomics Institute and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
Drug Response:
resistant
Cancer basic information
Cancer:
lung small cell carcinoma
Tissue/Cell:
cell line (H446, H446/CDDP )
Other information
Title:
Analysis of novel microRNA targets in drug-sensitive and -insensitive small cell lung cancer cell lines.
Journal:
Oncol Rep
Published:
2016
PubMed ID:
26676926