ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
PTEN/Akt pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00441 (APRD00201)
Drug Name:
Gemcitabine
Drug Method:
The expression levels of miRNA were determined by quantitative RT-PCR and those of protein were by Western blot analysis. The CCK-8 assay was used to monitor the growth of the cells. Cell migration was detected by transwell migration and invasion assay.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MDA-MB-231, MCF-7,)
Other information
Title:
MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer.
Journal:
Tumour Biol
Published:
2016
PubMed ID:
26666820