ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
miRBase
ncRNA Name:
miR-106~25
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
NA
ncRNA Target Gene:
EP300
ncRNA Pathway:
miR-106b~25 cluster/EP300/E-cadherin pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
The role of miR-106b~25 cluster in breast cancer cells was detected using drug resistance clonogenic assay, drug efflux assay, P-glycoprotein expression assay, Gene expression analysis, caspase-9 and -3/-7 using Caspase-Glo assays, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line
Other information
Title:
MiR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300.
Journal:
Oncol Rep
Published:
2016
PubMed ID:
26573761