ncRNA basic information
ncRNA ID:
MI0003130
ncRNA Database:
miRBase
ncRNA Name:
miR-202
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PDCD4
ncRNA Pathway:
TGF-Beta1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
miR-202 expression was measured by real-time PCR in patient tissues, cell lines or cells treated with TGF-Beta1, using siRNA to knock down the expression of Smad2, Smad3 and Smad4. miR-202 mimics, inhibitor and scramble siRNA were transfected into osteosarcoma cells to observe effects on cell apoptosis and drug resistance. Moreover, relationships of miR-202 level with PDCD4 were investigated by luciferase reporter assay, real-time PCR and Western blotting.
Drug Response:
resistant
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (U2OS, G293)
Other information
Title:
TGF-Beta1-induced miR-202 mediates drug resistance by inhibiting apoptosis in human osteosarcoma.
Journal:
J Cancer Res Clin Oncol
Published:
2016
PubMed ID:
26276504