ncRNA basic information
ncRNA ID:
MI0000681
ncRNA Database:
miRBase
ncRNA Name:
miR-155
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
SOCS6
ncRNA Pathway:
SOCS6-STAT3 signalling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
This study investigated the mechanism of TAM resistance of mir-155 in breast cancer.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
tissue and cell line (MCF7, SKBR3 )
Other information
Title:
MiRNA-155 mediates TAM resistance by modulating SOCS6-STAT3 signalling pathway in breast cancer.
Journal:
Am J Transl Res
Published:
2015
PubMed ID:
26692956