ncRNA basic information
ncRNA ID:
MI0000270/MI0000683
ncRNA Database:
miRBase
ncRNA Name:
miR-181b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
TGFBetaR1/Smad signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real time-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. A wound healing assay was performed to examine the capacity of cell migration. Cell migration was detected by transwell migration and invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549, A549/DDP, H1650 )
Other information
Title:
MiR-181b regulates cisplatin chemosensitivity and metastasis by targeting TGFBetaR1/Smad signaling pathway in NSCLC.
Journal:
Sci Rep
Published:
2015
PubMed ID:
26620926