ncRNA basic information
ncRNA ID:
NA
ncRNA Database:
miRBase
ncRNA Name:
chr15-10055
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
HCT-8 colon carcinoma cells were cultured and treated with different VCR concentrations to establish an HCT-8/VCR resistant cell line. Whole-genome screens, HiSeq 2500 sequencing, and bioinformatics methods were used to detect and analyze differences in miRNA expression between the drug-resistant HCT-8/VCR cells and non-resistant HCT-8 cells. Differential expression profiles of miRNAs were constructed based on sequencing result.
Drug Response:
resistant
Cancer basic information
Cancer:
colon cancer
Tissue/Cell:
cell line (HCT-8, HCT-8/VCR)
Other information
Title:
Deep sequencing identifies deregulation of microRNAs involved with vincristine drug-resistance of colon cancer cells.
Journal:
Int J Clin Exp Pathol
Published:
2015
PubMed ID:
26617885