ncRNA basic information
ncRNA ID: NA
ncRNA Database: miRBase
ncRNA Name: chr15-10055
ncRNA Type: miRNA
ncRNA Expression: up-regulated
ncRNA Method: PCR
ncRNA Target Gene: NA
ncRNA Pathway: NA
Evidence (ncRNA-drug): predicted
drug basic information
Drug ID: DB00541 (APRD00495)
Drug Name: Vincristine
Drug Method: HCT-8 colon carcinoma cells were cultured and treated with different VCR concentrations to establish an HCT-8/VCR resistant cell line. Whole-genome screens, HiSeq 2500 sequencing, and bioinformatics methods were used to detect and analyze differences in miRNA expression between the drug-resistant HCT-8/VCR cells and non-resistant HCT-8 cells. Differential expression profiles of miRNAs were constructed based on sequencing result.
Drug Response: resistant
Cancer basic information
Cancer: colon cancer
Tissue/Cell: cell line (HCT-8, HCT-8/VCR)
Other information
Title: Deep sequencing identifies deregulation of microRNAs involved with vincristine drug-resistance of colon cancer cells.
Journal: Int J Clin Exp Pathol
Published: 2015
PubMed ID: 26617885