ncRNA basic information
ncRNA ID:
MI0000283
ncRNA Database:
miRBase
ncRNA Name:
miR-203
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
Bcl-w, Survivin
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. The CCK-8 assay was used to monitor the growth of the cells.TUNEL staining was used to detect apoptotic cell death.
Drug Response:
sensitive
Cancer basic information
Cancer:
bladder cancer
Tissue/Cell:
tissue and cell line (5637,T24 , HEK 293T)
Other information
Title:
MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin.
Journal:
PLoS One
Published:
2015
PubMed ID:
26599571