ncRNA basic information
ncRNA ID:
MI0000474
ncRNA Database:
miRBase
ncRNA Name:
miR-134
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ABCC1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by Quantitative real-time polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/ADR)
Other information
Title:
MicroRNA-134 modulates resistance to doxorubicin in human breast cancer cells by downregulating ABCC1.
Journal:
Biotechnol Lett
Published:
2015
PubMed ID:
26318721