ncRNA basic information
ncRNA ID:
MIMAT0000250
ncRNA Database:
miRBase
ncRNA Name:
miR-139-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
Real-time quantitative PCR
ncRNA Target Gene:
Notch1
ncRNA Pathway:
Notch signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01248 (APRD00932)
Drug Name:
Docetaxel
Drug Method:
MiR-139-5p expression in MCF-7, MCF-7/Doc cells and in selected breast cancer tissue samples was confirmed by real-time PCR; cell viability was analyzed by Cell Counting Kit-8 assay; apoptosis and cell cycle were analyzed by flow cytometry; control of metastasis and invasion of breast cancer cells was measured by transwell assay; expression of Notch1 was measured by western blot; a luciferase reporter vector was constructed to identify the miR-139-5p target gene.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7,MCF-7/Doc)
Other information
Title:
MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel.
Journal:
Biochem Biophys Res Commun
Published:
2015
PubMed ID:
26299922